pgp - publications

Predict more pgp - ligand interactions now!

1. J Nucl Med Technol. 2012 Apr 13. [Epub ahead of print]

Abundant Blood Supply and Low P-Glycoprotein Expression on Dynamic 99mTc-MIBI
Imaging Predicted Better Chemotherapy Sensitivity for a Breast Cancer Patient: A
Case Report.

Si H, Li X.

1Department of Nuclear Medicine, First Affiliated Hospital of Anhui Medical
University, Hefei, Anhui Province, China; and.

A patient with a history of breast cancer underwent 3-phase (99m)Tc-methylene
diphosphonate (MDP) imaging followed 3 d later by 3-phase (99m)Tc-sestamibi
(MIBI) imaging. During the vascular and blood-pool phases, a lymph node over the
right clavicle was seen on both the (99m)Tc-MIBI and the (99m)Tc-MDP scans at as
early as 30 s and then became hotter. Four months after receiving chemotherapy,
the patient achieved a complete response. The lymph node over the right clavicle
vanished on ultrasound examination. The similar distribution of the blood-pool
phase between the (99m)Tc-MDP and (99m)Tc-MIBI scans indicated that (99m)Tc-MIBI
may similarly provide information on vascularization of the lymph node. In
addition to indicating vascularization, our (99m)Tc-MIBI protocol may
simultaneously provide information on P-glycoprotein expression important for
predicting chemotherapy sensitivity. With information on the resistance of a
tumor to drugs and the environment in which it dwells, chemotherapy sensitivity
might be predicted more precisely.

PMID: 22505488 [PubMed - as supplied by publisher]