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Effect of quercetin on P-glycoprotein transport ability in Chinese healthy subjects.


Eur J Clin Nutr. 2013 Feb 20;


Authors: Wang SY, Duan KM, Li Y, Mei Y, Sheng H, Liu H, Mei X, Ouyang W, Zhou HH, Liu ZQ


Abstract

Objectives:The aim of this study was to investigate the effect of quercetin on P-glycoprotein (P-gp) transport ability in vivo.Subjects/Methods:Genotype data were available from a total of 165 health volunteers. An open, randomized, two-period crossover clinical trial was performed in eighteen subjects with different MDR1 3435 C/T genotypes. All subjects took 500 mg quercetin or placebo daily from 1st to 13th day or from 43st to 55th day, and 100 mg talinolol was given at the 14th or 56th day. The washout period is 28 days.Results:In this study, we found the values of area under the curve (AUC)(0-48) (h), AUC(0-∞) and C(max) of talinolol in all subjects significantly decreased (6496.6±2389.9 vs 7809.5±2386.8 ng.h/ml, P=0.04), (8414.7±344.8 vs 10478.2±4195.4 ng.h/ml, P=0.03), (412.9±132.6 vs 543.3±97.9 ng.h/ml, P=0.01) after administration of quercetin, respectively. There were no significant differences in t(max) and t(1/2) of talinolol. The results also showed AUC(0-48) (h) (5598.6±2202.1 vs 8229.4±1491.7 ng.h/ml, P=0.02) and AUC(0-∞) (7110.0±3437.0 vs 12681.2±4828.2 ng.h/ml, P=0.01) of talinolol to be significantly decreased in MDR1 3435 TT individuals administered of quercetin. The C(max) of talinolol in MDR1 3435 TT (382.4±149.1 vs 584.9±115.2 ng/ml, P=0.04) and MDR1 3435 CT (383.5±104.9 vs 554.6±80.6 ng/ml, P=0.01) individuals significantly decreased after the administration of quercetin.Conclusions:Quercetin significantly induced the activity of P-gp and this induced effect was more obvious in MDR1 3435 TT individuals.European Journal of Clinical Nutrition advance online publication, 20 February 2013; doi:10.1038/ejcn.2013.5.

PMID: 23422925 [PubMed - as supplied by publisher]