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[Expression and clinical significance of P-gp in colonic gland of chronic schistosomiasis patients].


Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2012 Jun;24(3):290-3


Authors: Feng LS, Duan YP, Wu ZS, Li JJ, Wu J, Zhang AF, Zhang DK, Wang JD


Abstract

OBJECTIVE: To study the expression of P-glycoprotein (P-gp) in patients with chronic schistosomiasis and its relationship with gender and age, and to explore its clinical significance.

METHODS: The colonic mucosa specimens of 50 chronic schistosomiasis patients and 4 persons who had a family history of colon cancer but their physical examinations were normal (as a control group) were selected and the expressions of P-gp in the colonic gland of these samples were detected with the immunohistochemical staining method.

RESULTS: Compared with the control group, the mean gray value of the positive particles of P-gp of colonic epithelial cells of the chronic schistosomiasis group was significantly reduced (P < 0.05), but positive unit values were significantly increased (P < 0.05), which meant the P-gp expression in colonic gland of the patients with chronic schistosomiasis was significantly increased, but this increase had no relationship with sex and age.

CONCLUSION: Chronic schistosomiasis may induce the increase of P-gp expression which may be a compensatory protection mechanism due to the stimulation of schistosome eggs to the colon tissues.

PMID: 23012951 [PubMed - in process]