pgp - publications

Predict more pgp - ligand interactions now!



Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines.


Phytochemistry. 2012 Oct 15;


Authors: Jadranin M, Pešić M, Aljančić IS, Milosavljević SM, Todorović NM, Podolski-Renić A, Banković J, Tanić N, Marković I, Vajs VE, Tešević VV


Abstract

Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).

PMID: 23079764 [PubMed - as supplied by publisher]