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1. Reprod Toxicol. 2012 Feb 8. [Epub ahead of print]

Maternal undernutrition reduces P-glycoprotein in guinea pig placenta and
developing brain in late gestation.

Soo PS, Hiscock J, Botting KJ, Roberts CT, Davey AK, Morrison JL.

Early Origins of Adult Health Research Group, School of Pharmacy and Medical
Sciences, Sansom Institute for Health Research, University of South Australia,
Adelaide, SA, Australia, 5001.

Poor nutrition is a major cause of fetal growth restriction which increases
neonatal morbidity and mortality, as well as the risk of adult onset diseases.
The objective of the study was to determine the effect of maternal undernutrition
on P-glycoprotein (P-gp) expression in the placenta and the brain of both the
mother and the fetus. Maternal undernutrition in guinea pigs caused placental
restriction, and thus decreased fetal weight. Pups in the maternal undernutrition
(UN) group had fewer capillaries in the placenta and more capillaries in the
brain of the fetus. Placental, maternal and fetal brain MDR1 mRNA expression was
the same in the Control and UN groups. Maternal undernutrition resulted in a
significant decrease in P-gp protein expression in the placenta and fetal brain,
but not the maternal brain. These findings indicate that maternal undernutrition
may impact on fetal exposure to drugs administered to the mother during pregnancy
due to changes in placental transfer.

Copyright © 2012. Published by Elsevier Inc.

PMID: 22326852 [PubMed - as supplied by publisher]