pgp - publications

Predict more pgp - ligand interactions now!


1. Res Vet Sci. 2012 May 1. [Epub ahead of print]

P-glycoprotein expression in canine mammary gland tumours related with
myoepithelial cells.

Kim NH, Hwang YH, Im KS, Kim JH, Chon SK, Kim HY, Sur JH.

Department of Veterinary Pathology, Small Animal Tumour Diagnostic Centre,
College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu,
Seoul 143-701, Republic of Korea.

P-glycoprotein is influential in chemotherapy-resistance in numerous cancers and
has been widely studied in human breast cancer research, but is less studied in
canine mammary gland tumour (MGT). The study was to evaluate P-glycoprotein
expression and its localisations related with prognostic factors with monoclonal
antibody C219, by immunohistochemistry (IHC) of 68 cases of canine malignant
(n=54) and benign (n=14) MGT. Additional immunofluorescence (IF) and reverse
transcriptase-polymerase chain reaction (RT-PCR) were also performed. There was a
novel finding that P-glycoprotein expression with C219 localised at two different
cell types: epithelial and myoepithelial cells. Myoepithelial localised tumours
were 5 benign (35.5%) and 21 malignant (63.6%), while epithelial localised
tumours were 12 cases, all malignant (36.5%). Unlike conventional belief,
semi-quantitative evaluation of IHC intensity scores of C219 expression in
malignant MGT was related with favourable histopathological parameters.

Copyright © 2012 Elsevier Ltd. All rights reserved.

PMID: 22554937 [PubMed - as supplied by publisher]