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Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.

Bioorg Med Chem Lett. 2013 Jan 5;

Authors: Contino M, Zinzi L, Perrone MG, Leopoldo M, Berardi F, Perrone R, Colabufo NA


Compounds 8a-d have been designed as bioisosters of tariquidar for imaging P-gp expression and density by PET. The results displayed that compounds 8b and 8d could be considered potential P-gp/BCRP ligands suitable as (11)C and (18)F radiotracers, respectively.

PMID: 23374872 [PubMed - as supplied by publisher]