pgp - publications

Predict more pgp - ligand interactions now!



Single molecule tracking of P-glycoprotein in live cells reveals dynamic heterogeneity.


Conf Proc IEEE Eng Med Biol Soc. 2012 Aug;2012:3159-62


Authors: Cheney PP, Stachler MD, Knowles MK


Abstract

P-glycoprotein transports chemotherapy drugs from the plasma membrane and allows cancer cells to survive treatment. We transiently transfected PGP labeled with enhanced green fluorescent protein (PGP-EGFP) into MES-SA cells and used single molecule tracking techniques to characterize the dynamics on the surface of live cells. PGP exhibits freely diffusive behavior at short times and is confined at long times with a transition to anomalous diffusion at 0.7 s.

PMID: 23366596 [PubMed - in process]